Naturopathic Approach to Endometriosis: Top Supplements
Healthy View
Written by: Dr. Madison Sangster-Newbery, ND, Naturopathic Doctor, Adelaide Health Clinic & Sport Medicine Clinic
Endometriosis is a condition where tissue resembling the uterine lining grows outside the uterus. These misplaced tissues respond to hormonal changes, leading to inflammation, pain, immune dysfunction, and sometimes infertility. Many people feel frustrated with treatment options, so looking at a holistic approach - particularly one that includes targeted supplementation - can offer extra support and compliment conventional care. Below are my top supplement recommendations, along with some naturopathic insights on managing endometriosis.
Addressing the Whole Person
Naturopathic medicine focuses on treating the root causes of health concerns. For endometriosis, this means looking at hormones, liver function, gut health, inflammation, and stress levels. While supplements can be powerful, everyone’s situation is unique. Adjusting diet, managing stress, and getting regular exercise are also key pieces of the puzzle.
Ginger: A Natural Pain Reliever
Ginger is a favourite remedy for menstrual pain. Research shows that it can rival nonsteroidal anti-inflammatory drugs (like ibuprofen) in reducing endometriosis-related pain. But that’s not all - ginger may also soothe digestive issues, which often flare up around menstruation. Taking ginger in a concentrated supplement form ensures you’re getting a therapeutic dose without having to consume large amounts of the fresh root.
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Melatonin: More Than Just Sleep Support
Melatonin is well-known for its role in sleep regulation, but it also offers powerful antioxidant benefits. Studies indicate it may significantly reduce endometriosis pain and lessen the need for pain medications. Animal research further suggests melatonin might help shrink and slow the growth of endometrial lesions. Taking it before bed could improve both sleep quality and pain management - two critical factors when dealing with endometriosis.
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N-Acetyl Cysteine (NAC): The Multi-Purpose Tool
NAC is derived from the amino acid L-cysteine and is particularly useful for its anti-inflammatory and antioxidant properties. One of its key benefits is supporting the liver, which helps process and detoxify excess hormones - important if you have endometriosis. It may also boost immune function. Research shows that NAC supplementation may reduce the size of endometrial lesions and help lessen pain.
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Resveratrol: A Potent Antioxidant Powerhouse
Resveratrol, found in the skins of grapes and certain berries, is renowned for its anti-inflammatory and antioxidant effects. Studies suggest that it may aid in limiting new blood vessel formation in endometrial lesions and help trigger apoptosis (cell death) in problematic tissue. While resveratrol occurs naturally in red wine, you won’t get a therapeutic dose from a glass or two. In fact, alcohol can aggravate endometriosis symptoms, so a supplement form is your best bet.
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For an extra boost of antioxidants, consider adding more berries, dark leafy greens, and colourful vegetables to your diet, in addition to taking resveratrol supplements.
Vitamin D: The Sunshine Hormone
Vitamin D plays multiple roles in the body, from bone health to immune regulation. In endometriosis, research shows that supplementing with vitamin D may help reduce pelvic pain and lower inflammatory markers, while also improving cholesterol levels. If you live in a region with limited sunlight (like Canada), deficiency is more common, especially in winter.
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Vitamins C & E: The Antioxidant Duo
Vitamin C and Vitamin E two of the most researched antioxidants for endometriosis. Together, they can help reduce pain (including pelvic, menstrual, and intercourse-related pain) and lower overall inflammation and oxidative stress. Think of them as complementary players that support each other’s antioxidant activity.
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Other Naturopathic Considerations
- Diet: Following an anti-inflammatory eating plan (rich in vegetables, fruits, whole grains, and healthy fats) can help control endometriosis-related inflammation.
- Stress Management: Chronic stress can worsen hormonal imbalances. Practices like yoga, meditation, or breathwork can help calm the nervous system.
- Movement: Gentle to moderate exercise promotes blood flow, helps regulate hormone levels, and can ease stress.
- Personalized Care: Because endometriosis presents differently in each individual, working with a qualified naturopathic doctor can help tailor a plan that fits your unique needs.
Final Thoughts
Supplements can make a meaningful difference in managing endometriosis, but they work best as part of a holistic strategy. Supporting hormones, the liver, the immune system, and adopting a healthy and sustainable lifestyle all contribute to relief. If you’re considering any of these supplements, consult with a healthcare professional - especially if you’re on medication or have underlying conditions - to ensure safety and effectiveness.
By combining these targeted supplements with personalized naturopathic care, you can tackle endometriosis from multiple angles and feel more empowered in your health journey. If you're looking for a personalized approach to managing endometriosis, book an appointment with Dr. Madison Sangster-Newbery, ND. Together, we can find the best plan for your body and health goals!
Disclaimer: This blog post is for informational purposes only and is not medical advice. Always consult a qualified healthcare practitioner before making significant changes to your supplement routine. Everyone’s health picture is unique, and professional guidance ensures the best results.
About the Author
Dr. Madison Sangster-Newbery, ND, is a licensed and registered naturopathic doctor based in Ontario. She blends evidence-based medicine with traditional naturopathic principles to support general health and athletic performance, focusing on optimizing recovery, endurance, and overall well-being. Inspired by her own health journey, Dr. Madison specializes in hormonal balance, stress management, and holistic care tailored to active, dynamic lifestyles. Passionate about helping others thrive, especially during demanding times like the holidays, she provides personalized tools and strategies for achieving vitality and balance. Outside the clinic, Dr. Madison enjoys exploring nature, staying active on the squash court, and cooking for friends and family.
Dr. Madison Sangster-Newbery ND is currently licensed and registered to practice in Ontario under the College of Naturopaths of Ontario. She is a member of both the Ontario Association of Naturopathic Doctors and the Canadian Association of Naturopathic Doctors.
References
Amini L, Chekini R, Nateghi MR, Haghani H, Jamialahmadi T, Sathyapalan T, Sahebkar A. The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial. Pain Res Manag. 2021 May 26;2021:5529741. doi: 10.1155/2021/5529741. PMID: 34122682; PMCID: PMC8172324.
Keshavarzi F, Mahmoudzadeh F, Brand S, Sadeghi Bahmani D, Akbari F, Khazaie H, Ghadami MR. Both melatonin and meloxicam improved sleep and pain in females with primary dysmenorrhea-results from a double-blind cross-over intervention pilot study. Arch Womens Ment Health. 2018 Dec;21(6):601-609. doi: 10.1007/s00737-018-0838-x. Epub 2018 Apr 4. PMID: 29619605.
Maia H Jr, Haddad C, Pinheiro N, Casoy J. Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain. Int J Womens Health. 2012;4:543-9. doi: 10.2147/IJWH.S36825. Epub 2012 Oct 10. PMID: 23091400; PMCID: PMC3474155.
Mehdizadehkashi A, Rokhgireh S, Tahermanesh K, Eslahi N, Minaeian S, Samimi M. The effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis. Gynecol Endocrinol. 2021 Jul;37(7):640-645. doi: 10.1080/09513590.2021.1878138. Epub 2021 Jan 29. PMID: 33508990.
Mosher AA, Tsoulis MW, Lim J, Tan C, Agarwal SK, Leyland NA, Foster WG. Melatonin activity and receptor expression in endometrial tissue and endometriosis. Hum Reprod. 2019 Jul 8;34(7):1215-1224. doi: 10.1093/humrep/dez082. PMID: 31211323; PMCID: PMC6613342.
Negi R, Sharma SK, Gaur R, Bahadur A, Jelly P. Efficacy of Ginger in the Treatment of Primary Dysmenorrhea: A Systematic Review and Meta-analysis. Cureus. 2021 Mar 6;13(3):e13743. doi: 10.7759/cureus.13743. PMID: 33842121; PMCID: PMC8021506.
Ozgoli G, Goli M, Moattar F. Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. J Altern Complement Med. 2009 Feb;15(2):129-32. doi: 10.1089/acm.2008.0311. PMID: 19216660.
Porpora MG, Brunelli R, Costa G, Imperiale L, Krasnowska EK, Lundeberg T, Nofroni I, Piccioni MG, Pittaluga E, Ticino A, Parasassi T. A promise in the treatment of endometriosis: an observational cohort study on ovarian endometrioma reduction by N-acetylcysteine. Evid Based Complement Alternat Med. 2013;2013:240702. doi: 10.1155/2013/240702. Epub 2013 May 7. PMID: 23737821; PMCID: PMC3662115.
Rahnama P, Montazeri A, Huseini HF, Kianbakht S, Naseri M. Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial. BMC Complement Altern Med. 2012 Jul 10;12:92. doi: 10.1186/1472-6882-12-92. PMID: 22781186; PMCID: PMC3518208.
Santanam N, Kavtaradze N, Murphy A, Dominguez C, Parthasarathy S. Antioxidant supplementation reduces endometriosis-related pelvic pain in humans. Transl Res. 2013 Mar;161(3):189-95. doi: 10.1016/j.trsl.2012.05.001. Epub 2012 May 31. PMID: 22728166; PMCID: PMC3484190.
Schwertner A, Conceição Dos Santos CC, Costa GD, Deitos A, de Souza A, de Souza IC, Torres IL, da Cunha Filho JS, Caumo W. Efficacy of melatonin in the treatment of endometriosis: a phase II, randomized, double-blind, placebo-controlled trial. Pain. 2013 Jun;154(6):874-81. doi: 10.1016/j.pain.2013.02.025. Epub 2013 Mar 5. PMID: 23602498.